Comparison of two different assays and the predictive value of allergen components in house dust mite allergy

Schulze, Johannes; Leberkuehne, Lisanne; Salzmann-Manrique, Emilia; Schubert, Ralf; Zielen, Stefan und Rosewich, Martin (2017): Comparison of two different assays and the predictive value of allergen components in house dust mite allergy. In: Immunotherapy, Bd. 9, Nr. 15: S. 1253-1262

Abstract

Aim: In house dust mite (HDM) allergy diagnostics, the IMMULITE, ImmunoCAP and assays for allergen components (nDer p 1 and rDer p 2) are available. Methods: Serum sIgE levels were compared and the predictive values for the detection of an early asthmatic response (EAR) were calculated with receiver operating characteristics and a log-logistic regression model. Results: sIgE levels of IMMULITE and ImmunoCAP were similar (Dermatophagoides pteronyssinus [D. pter.]47.3 +/- 35.7 and 42.9 +/- 34.4kU.l(-1);p=0.23). ImmunoCAP slgEs exhibited similar accuracy in detecting an EAR, area under the curves (AUCs): D. pter. (0.76);Dermatophagoides farinae (0.79);nDer p 1 (0.69);and rDer p 2 (0.72). At low sIgE concentrations (3.5kU.l(-1)), rDer p 2 was more specific and better predicted an EAR (probability rDer p 2: 62%;D. pter.: 19%).

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1750-743X
• Sprache: Englisch