Abstract
Background: Given that many studies suggest a role of DLPFC-sgACC connectivity in depression and prior research demonstrating that neuromodulation of either of these nodes modulates parasympathetic activity and results in a heart rate deceleration, a new method is proposed to individualize localization of the DLPFC. This can, among others, be useful for rTMS treatment of depression. Methods: Ten healthy subjects received three trains of 10Hz rTMS randomly over 7 target regions (10-20 system). Results: Overall, F3 and F4 expressed the largest heart rate deceleration, in line with studies suggesting these are the best 10-20 sites to target the DLPFC. On the individual level, 20-40% subjects expressed the largest heart rate deceleration at FC3 or FC4, indicating individual differences as to the 'optimal site for stimulation'. Conclusions: These results show that the NCG-TMS method is valid to localize the entry into the DLPFC-sgACC network.
Item Type: | Journal article |
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Faculties: | Medicine |
Subjects: | 600 Technology > 610 Medicine and health |
ISSN: | 1935-861X |
Language: | English |
Item ID: | 52506 |
Date Deposited: | 14. Jun 2018, 09:50 |
Last Modified: | 04. Nov 2020, 13:31 |