Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia

Dickinson, Anne M.; Norden, Jean; Li, Shuang; Hromadnikova, Ilona; Schmid, Christoph; Schmetzer, Helga and Jochem-Kolb, Hans (2017): Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia. In: Frontiers in Immunology, Vol. 8, 496

Abstract

The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1664-3224
• Language: English