Repair of large saddle defects of the mandibular ridge using dual growth factor releaseAn experimental pilot study in minipigs

Tröltzsch, Markus; Klenke, Alexander; Santander, Petra; Kauffmann, Philipp; Tröltzsch, Matthias; Rau, Anna; Brockmeyer, Phillip und Schliephake, Henning (2017): Repair of large saddle defects of the mandibular ridge using dual growth factor releaseAn experimental pilot study in minipigs. In: Journal of Clinical Periodontology, Bd. 44, Nr. 8: S. 854-863

Abstract

AimTo test the hypothesis that the addition of small amounts of rhVEGF to rhBMP2 in a polymer carrier can accomplish equivalent repair effect as a reduced dosage of rhBMP2 compared to rhBMP2 alone. Materials and MethodsDefects were created bilaterally in the mandibles of 18 minipigs. In 12 test animals, defects were filled with 0.5g particulate PDLLA/CaCO3 composite loaded with 400g rhBMP2/50g rhVEGF165 on one side and 800g rhBMP2 on the other. After 4 and 13weeks, the animals were evaluated each for area of new bone formation (mm(2)) and bone density (area %). ResultsArea of newly formed bone was higher in defects with carriers loaded with 400g rhBMP2 50 mu g VEGF165 than in defects with 800g rhBMP2 after 4weeks (11.97 versus 7.97mm(2);p=0.043) and 13weeks (72.48 versus 62.2mm(2);p=.028). Defects filled with blank carrier exhibited less bone after 13weeks (42.75mm(2);p=.039 and .020 respectively). ConclusionsDelivery of rhBMP2 from a polymer carrier can improve repair of large saddle defects of the mandibular ridge. Addition of small amounts of rhVEGF can increase bone formation and at the same time reduce the dosage of rhBMP2.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0303-6979
• Sprache: Englisch