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Siroky, Brian J.; Towbin, Alexander J.; Trout, Andrew T.; Schäfer, Hannah; Thamann, Anna R.; Agricola, Karen D.; Tudor, Cynthia; Capal, Jamie; Dixon, Bradley P.; Krueger, Darcy A.; Franz, David N. (2017): Improvement in Renal Cystic Disease of Tuberous Sclerosis Complex After Treatment with Mammalian Target of Rapamycin Inhibitor. In: Journal of Pediatrics, Vol. 187: pp. 318-322
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Abstract

Renal cysts occur in approximately 50% of patients with tuberous sclerosis complex, but their clinical significance and response to treatment are unknown. Abdominal imaging of 15 patients with tuberous sclerosis complex-associated renal cystic disease who had received mammalian target of rapamycin inhibitor therapy for other tuberous sclerosis complex-related indications was evaluated. Reductions in cyst number, sum diameter, and volume were observed.