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Wachinger, Christian; Brennan, Matthew; Sharp, Greg C. und Golland, Polina (2017): Efficient Descriptor-Based Segmentation of Parotid Glands With Nonlocal Means. In: Ieee Transactions On Biomedical Engineering, Bd. 64, Nr. 7: S. 1492-1502

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Abstract

Objective: We introduce descriptor-based segmentation that extends existing patch-based methods by combining intensities, features, and location information. Since it is unclear which image features are best suited for patch selection, we perform a broad empirical study on a multitude of different features. Methods: We extend nonlocal means segmentation by including image features and location information. We search larger windows with an efficient nearest neighbor search based on kd-trees. We compare a large number of image features. Results: The best results were obtained for entropy image features, which have not yet been used for patch-based segmentation. We further show that searching larger image regions with an approximate nearest neighbor search and location information yields a significant improvement over the bounded nearest neighbor search traditionally employed in patch-based segmentation methods. Conclusion: Features and location information significantly increase the segmentation accuracy. The best features highlight boundaries in the image. Significance: Our detailed analysis of several aspects of nonlocal means-based segmentation yields new insights about patch and neighborhood sizes together with the inclusion of location information. The presented approach advances the state-of-the-art in the segmentation of parotid glands for radiation therapy planning.

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