A Biosurfactant-Inspired Heptapeptide with Improved Specificity to Kill MRSA

Liu, Yuan; Ding, Shuangyang; Dietrich, Richard; Märtlbauer, Erwin und Zhu, Kui (2017): A Biosurfactant-Inspired Heptapeptide with Improved Specificity to Kill MRSA. In: Angewandte Chemie-international Edition, Bd. 56, Nr. 6: S. 1486-1490

Abstract

The emergence and rapid spread of methicillin-resistant Staphylococcus aureus (MRSA) poses a serious threat to public health. New antibiotics and strategies are urgently needed to combat S. aureus associated infections. Bacaucin, a novel cyclic lipopeptide from Bacillus subtilis CAU21, is reported. Bacaucin shows broad antibacterial activity against Gram-positive bacteria, but is also hemolytic and cytotoxic. However, bacaucin-1, a bacaucin-inspired ring-opened heptapeptide, shows specific antibacterial activity against MRSA by a membrane-disruptive mechanism without detectable toxicity to mammalian cells or induction of bacterial resistance. Bacaucin-1 was efficient in preventing infections in both in vitro and in vivo models and is a valuable prototype antibiotic with high potential against S. aureus infections.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Tiermedizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1433-7851
• Sprache: Englisch