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Matiasek, Kaspar; Rosati, Marco (2017): Feline Temporallappenepilepsie – Was lernen wir von unseren Katzen? In: Zeitschrift für Epileptologie, Vol. 30, No. 3: pp. 213-217
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Abstract

Feline (Felis silvestris catus) temporal lobe epilepsy (FTLE) shows quite characteristic magnetic resonance imaging features and is frequently accompanied by orofacial automatisms. In histological investigations the most common changes underlying FTLE are separate or combined necrotizing limbic encephalitis (LE) and hippocampal sclerosis (HS). In analogy to human LE, many feline cases (FLE) have been associated with an autoimmune response with circulating autoantibodies. FLE is consistently accompanied by bilateral HS with affection of all segments of the cornu ammonis (CA), while less than 5% of other epilepsy-associated brain lesions in cats involve both hippocampi. As expected the majority (76.3%) of FHS cases result from disruptive hippocampal pathologies;however, at lower prevalence extrahippocampal forebrain lesions (26.7%) and systemic metabolic abnormalities (37.5%) in the course of epilepsy can also result in FHS. Thereby, extrahippocampal changes usually affect single CA segments only. As cats appear to differ in some limbic circuits, neurobiological conclusions on the segmental pattern of FHS awaits functional elucidation of the affected synaptic connections. As FHS is associated with recrudescent epilepsy courses, FTLE resembles a promising natural animal model for exploration of mechanisms of epileptogenesis, epilepsy progression and drug resistance.