Logo Logo
Hilfe
Hilfe
Switch Language to English

Illes, Bernhard; Wuttke, Stefan und Engelke, Hanna (2017): Liposome-Coated Iron Fumarate Metal-Organic Framework Nanoparticles for Combination Therapy. In: Nanomaterials, Bd. 7, Nr. 11, 351 [PDF, 2MB]

[thumbnail of ijerph-14-00426-v2.pdf]
Vorschau
Download (2MB)

Abstract

One of the main problems for effective treatment of cancer is resistances, which often require combination therapyfor effective treatment. While there are already some potential drug carrierse.g., liposomes, available for treatmentthe effective loading and retention of the desired drug ratio can be challenging. To address this challenge, we propose a new type of drug carrier: liposome-coated metal-organic framework (MOF) nanoparticles. They combine the advantages of liposomes with an easy and efficient loading process. In this work, we present the successful synthesis of liposome-coated MOF nanoparticles via the fusion method. The resulting particles, once loaded, show no premature leakage and an efficient release. Their successful loading with both single and multiple drugs at the same time makes them an interesting candidate for use in combination therapy.

Dokument bearbeiten Dokument bearbeiten