Synthesis and Functionalization of Ordered Large-Pore Mesoporous Silica Nanoparticles for Biomedical Applications

Chiu, Hsin-Yi; Leonhardt, Heinrich und Bein, Thomas (2017): Synthesis and Functionalization of Ordered Large-Pore Mesoporous Silica Nanoparticles for Biomedical Applications. In: Chemie ingenieur Technik, Bd. 89, Nr. 7: S. 876-886

Abstract

A dual surfactant synthetic approach was employed for the synthesis of large-pore mesoporous silica nanoparticles (MSNs). The as-synthesized mesoporous silica exhibited not only 2D hexagonal mesostructure with an average pore size of about 7nm but also a spherical nanoparticulate morphology. A delayed co-condensation synthesis method was further employed to create site-specific core-shell bifunctional MSNs. These core-shell large-pore MSNs are biocompatible and can be efficiently taken up by cells. They are therefore promising nanocarriers for cellular delivery purposes.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Fakultätsübergreifende Einrichtungen: Center for Integrated Protein Science Munich (CIPSM)
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0009-286X
• Sprache: Englisch