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Chiu, Hsin-Yi; Leonhardt, Heinrich; Bein, Thomas (2017): Synthesis and Functionalization of Ordered Large-Pore Mesoporous Silica Nanoparticles for Biomedical Applications. In: Chemie ingenieur Technik, Vol. 89, No. 7: pp. 876-886
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A dual surfactant synthetic approach was employed for the synthesis of large-pore mesoporous silica nanoparticles (MSNs). The as-synthesized mesoporous silica exhibited not only 2D hexagonal mesostructure with an average pore size of about 7nm but also a spherical nanoparticulate morphology. A delayed co-condensation synthesis method was further employed to create site-specific core-shell bifunctional MSNs. These core-shell large-pore MSNs are biocompatible and can be efficiently taken up by cells. They are therefore promising nanocarriers for cellular delivery purposes.