Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2

Cheng, Bichu; Müller, Rolf und Trauner, Dirk (2017): Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2. In: Angewandte Chemie-international Edition, Bd. 56, Nr. 41: S. 12755-12759

Abstract

The cystobactamids are a family of antibacterial natural products with unprecedented chemical scaffolds that are active against both Gram-positive and Gram-negative pathogens. Herein, we describe the first total synthesis of cystobactamid 919-2 from three fragments. Our convergent synthesis enabled both the confirmation of the correct structure and the determination of the absolute configuration of cystobactamid 919-2.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1433-7851
• Sprache: Englisch