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Cheng, Bichu; Müller, Rolf; Trauner, Dirk (2017): Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2. In: Angewandte Chemie-international Edition, Vol. 56, No. 41: pp. 12755-12759
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Abstract

The cystobactamids are a family of antibacterial natural products with unprecedented chemical scaffolds that are active against both Gram-positive and Gram-negative pathogens. Herein, we describe the first total synthesis of cystobactamid 919-2 from three fragments. Our convergent synthesis enabled both the confirmation of the correct structure and the determination of the absolute configuration of cystobactamid 919-2.