Total Synthesis of CrocaginA

Bihelovic, Filip; Stichnoth, Desiree; Surup, Frank; Müller, Rolf and Trauner, Dirk (2017): Total Synthesis of CrocaginA. In: Angewandte Chemie-international Edition, Vol. 56, No. 42: pp. 12848-12851

Abstract

CrocaginA (1) combines an attractive molecular structure with an unusual biosynthesis and bioactivity. An efficient synthesis of crocaginA is presented that hinges on an early formation of the heterotricyclic core, an electrophilic amination, and the stereoselective hydrogenation of a tetrasubstituted double bond. This synthesis confirms the absolute configuration of crocaginA and provides access to the natural product and derivatives thereof for further biological testing.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1433-7851
• Language: English