Synthesis and utilization of optically active alpha-aminophosphonate derivatives by Kabachnik-Fields reaction

Balint, Erika; Tajti, Adam; Kalocsai, Dorottya; Matravolgyi, Bela; Karaghiosoff, Konstantin; Czugler, Matyas und Keglevich, Gyorgy (2017): Synthesis and utilization of optically active alpha-aminophosphonate derivatives by Kabachnik-Fields reaction. In: Tetrahedron, Bd. 73, Nr. 38: S. 5659-5667

Abstract

(S)-alpha-Phenylethylamine was used in the microwave-assisted Kabachnik-Fields condensation with paraformaldehyde and > P(O)H species, such as dialkyl phosphites, ethyl phenyl-H-phosphinate and diphenylphosphine oxide to provide optically active alpha-aminophosphonates, alpha-aminophosphinate and alpha-aminophosphine oxide, or using a two equivalent quantity of paraformaldehyde and (RO)(2)P(O)H or Ph2P(O)H, bis(phosphonomethyl)amines and bis(phosphinoylmethyl)amine, respectively. The bis(phosphinoylmethyl)amine served as a precursor for an optically active bidentate P-ligand in the synthesis of a chiral platinum complex.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0040-4020
• Sprache: Englisch