Abstract
A mild and general set of Metalation procedures for the functionalization of unsymmetrical azobenzenes using a commercially available continuous-flow setup is reported. The metalations proceed with TMPLi under convenient conditions (0 C-omicron, 20 s), and various classes of electrophiles can be used. With sensitive substrates, an in situ trapping metalation in which TMPLi is added to a mixture of the azobenzene and ZnCl2 or MgCl2 center dot LiCl was very effective for achieving high yields.
Dokumententyp: | Zeitschriftenartikel |
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Fakultät: | Chemie und Pharmazie > Department Chemie |
Themengebiete: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
ISSN: | 1523-7060 |
Sprache: | Englisch |
Dokumenten ID: | 54350 |
Datum der Veröffentlichung auf Open Access LMU: | 14. Jun. 2018, 09:56 |
Letzte Änderungen: | 04. Nov. 2020, 13:34 |