Methods for the Synthesis of Substituted Azetines

Baumann, Andreas N.; Eisold, Michael; Music, Arif; Haas, Geoffrey; Kiw, Yu Min and Didier, Dorian (2017): Methods for the Synthesis of Substituted Azetines. In: Organic Letters, Vol. 19, No. 20: pp. 5681-5684

Abstract

Spurred on by the recent emerging interest from the chemical community for unsaturated four-membered heterocycles, an unprecedented approach to nitrogen-containing four-membered rings has been designed. 3,4-Disubstituted 2-azetines were synthesized from commercially available substrates, allowing for a straightforWard access to a new library of chiral functionalized azetidines and amino alcohols. This original approach was applied to efficiently prepare functionalized azobenzenes, an emerging class of molecules with a large potential in photopharmacology.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1523-7060
• Language: English