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Torres-Duarte, Cristina; Ramos-Torres, Karla M.; Rahimoff, Rene; Cherr, Gary N. (2017): Stage specific effects of soluble copper and copper oxide nanoparticles during sea urchin embryo development and their relation to intracellular copper uptake. In: Aquatic Toxicology, Vol. 189: S. 134-141
Volltext auf 'Open Access LMU' nicht verfügbar.

Abstract

The effects of exposure to either soluble copper (copper sulfate) or copper oxide nanoparticles (nano-CuO) during specific early developmental stages of sea urchin embryos were analyzed. Soluble copper caused significant malformations in embryos (skeletal malformations, delayed development or gut malformations) when present at any given stage, while cleavage stage was the most sensitive to nano-CuO exposure causing skeletal malformations and decreased total antioxidant capacity. The stage specificity was linked to higher endocytic activity during the first hours of development that leads to higher accumulation of copper in specific cells critical for development. Results indicate that nano-CuO results in higher accumulation of copper inside of embryos and this intracellular copper. The possible implications later in development are discussed.