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Baumann, Andreas N.; Eisold, Michael; Didier, Dorian (2017): Stereoselective Sequence toward Biologically Active Fused Alkylidenecyclobutanes. In: Organic Letters, Vol. 19, No. 8: pp. 2114-2117
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Abstract

Combining an efficient preparation of cyclobutenylmetal species, high-yielding cross-coupling reactions, and highly diastereoselective [4 + 2]-cycloaddition led to opening a new route toward the synthesis of fused alkylidenecyclobutanes containing up to five consecutive stereocenters. New complex architectures, analogues to protoilludane skeletons, were obtained in a very efficient manner and with a minimum number of steps starting from commercial sources and were tested for their cytotoxicity against leukemia cell lines HL60.