Stereoselective Sequence toward Biologically Active Fused Alkylidenecyclobutanes

Baumann, Andreas N.; Eisold, Michael and Didier, Dorian (2017): Stereoselective Sequence toward Biologically Active Fused Alkylidenecyclobutanes. In: Organic Letters, Vol. 19, No. 8: pp. 2114-2117

Abstract

Combining an efficient preparation of cyclobutenylmetal species, high-yielding cross-coupling reactions, and highly diastereoselective [4 + 2]-cycloaddition led to opening a new route toward the synthesis of fused alkylidenecyclobutanes containing up to five consecutive stereocenters. New complex architectures, analogues to protoilludane skeletons, were obtained in a very efficient manner and with a minimum number of steps starting from commercial sources and were tested for their cytotoxicity against leukemia cell lines HL60.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1523-7060
• Language: English