Hippocampal Spike-Timing Correlations Lead to Hexagonal Grid Fields

Monsalve-Mercado, Mauro M. und Leibold, Christian (2017): Hippocampal Spike-Timing Correlations Lead to Hexagonal Grid Fields. In: Physical Review Letters, Bd. 119, Nr. 3, 38101

Abstract

Space is represented in the mammalian brain by the activity of hippocampal place cells, as well as in their spike-timing correlations. Here, we propose a theory for how this temporal code is transformed to spatial firing rate patterns via spike-timing-dependent synaptic plasticity. The resulting dynamics of synaptic weights resembles well-known pattern formation models in which a lateral inhibition mechanism gives rise to a Turing instability. We identify parameter regimes in which hexagonal firing patterns develop as they have been found in medial entorhinal cortex.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Biologie > Department Biologie II > Neurobiologie
• Fakultätsübergreifende Einrichtungen: Graduate School of Systemic Neurosciences (GSN)
• Themengebiete: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie ; 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften
• ISSN: 0031-9007
• Sprache: Englisch