Changes in extracellular pH during electrical stimulation of isolated rat vagus nerve

Endres, W.; Grafe, Peter; Bostock, Hugh und Ten Bruggencate, Gerrit (1986): Changes in extracellular pH during electrical stimulation of isolated rat vagus nerve. In: Neuroscience Letters, Bd. 64, Nr. 2: S. 201-205

Abstract

Double-barrelled pH-sensitive micro-electrodes were used to record changes of extracellular pH during repetitive stimulation of isolated rat vagus nerves. It was found that a small initial alkaline shift was followed by a prolonged acidification. The acidification was correlated in time with the poststimulus undershoot of the extracellular K+ activity and with the recovery phase of the nerve conduction velocity. In the presence of ouabain, the acid component of the pH change was completely abolished (indicating a metabolic origin), whereas the alkaline component remained unaltered. These pH changes were too small to make a significant contribution to the activity-related changes in conduction velocity of the vagal C-fibres.

• Dokumententyp: Zeitschriftenartikel
• Keywords: pH; vagus nerve; ion-sensitive micro-electrode; ouabain; excitability; rat
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit