Alkalinization during re-oxygenation prevents functional damage by hyperglycaemic hypoxia

Euchner-Wamser, Ingrid; Grafe, Peter; Sennefelder, Elke und Schneider, Uwe (1994): Alkalinization during re-oxygenation prevents functional damage by hyperglycaemic hypoxia. Membrane and Cellular Biophysics and Biochemistry. In: Neuroreport, Bd. 5, Nr. 13: S. 1574-1576

Abstract

HYPERGLYCAEMIA impairs recovery from transient cerebral ischaemia: the importance of tissue acidification for this phenomenon has not been clarified in detail. We investigated this issue in a less complex in vitro preparation of isolated rat dorsal spinal roots exposed for 30 min to hyperglycaemic hypoxia. Peak height of compound action potentials recovered minimally in 5 mM bicarbonate. However, recovery was greatly improved by addition of the weak base trimethylamine during re-oxygenation. Addition of the weak acid propionate had no such effect. Cytoplasmic alkalinization improved recovery in a brief time window only: application of trimethylamine after 15 min of re-oxygenation was without beneficial effect. These data emphasize the importance of cytoplasmic acidification for neurophysiological recovery from hyper-glycaemic hypoxia during the initial period of re-oxygenation.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0959-4965