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Soffietti, Riccardo; Abacioglu, Ufuk; Baumert, Brigitta; Combs, Stephanie E.; Kinhult, Sara; Kros, Johan M.; Marosi, Christine; Metellus, Philippe; Radbruch, Alexander; Freixa, Salvador S. Villa; Brada, Michael; Carapella, Carmine M.; Preusser, Matthias; Le Rhun, Emilie; Rudà, Roberta; Tonn, Joerg C.; Weber, Damien C.; Weller, Michael (2017): Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO). In: Neuro-Oncology, Vol. 19, Nr. 2: S. 162-174
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Abstract

The management of patients with brain metastases has become a major issue due to the increasing frequency and complexity of the diagnostic and therapeutic approaches. In 2014, the European Association of NeuroOncology (EANO) created a multidisciplinary Task Force to draw evidence-based guidelines for patients with brain metastases from solid tumors. Here, we present these guidelines, which provide a consensus review of evidence and recommendations for diagnosis by neuroimaging and neuropathology, staging, prognostic factors, and different treatment options. Specifically, we addressed options such as surgery, stereotactic radiosurgery/ stereotactic fractionated radiotherapy, whole-brain radiotherapy, chemotherapy and targeted therapy (with particular attention to brain metastases from non-small cell lung cancer, melanoma and breast and renal cancer), and supportive care.