Idiopathic interstitial pneumonia-associated pulmonary hypertension: A target for therapy?

Nathan, Steven D.; Behr, Jürgen; Coffin, Vincent; Collard, Harold R.; Hoeper, Marius M.; Martinez, Fernando J. and Wells, Athol U. (2017): Idiopathic interstitial pneumonia-associated pulmonary hypertension: A target for therapy? In: Respiratory Medicine, Vol. 122: S10-S13

Abstract

Advances in the treatment of idiopathic interstitial pneumonia (IIP) represent an urgent, unmet medical need for patients with this category of diffuse parenchymal lung disease. IIPs involve varying combinations of fibrosis and inflammation of unknown cause and may be associated with pulmonary hypertension (PH). When it occurs, PH is associated with higher oxygen needs, greater functional impairment, and increased mortality. However, whether or when PH is a maladaptive versus adaptive phenomenon remains to be determined. Despite their differing prognoses, it does appear that the IIPs may follow a similar course once PH supervenes. Therefore, it may be worthwhile to explore studies of PH medications in IIP as a group rather than as individual entities. Such a broad approach eliminates the need to nuance specific diagnoses and thereby facilitates study recruitment and broadens the applicability of the results. (C) 2016 Published by Elsevier Ltd.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0954-6111
• Language: English