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Procházková, Kristyna; Staehler, Michael; Trávníček, Ivan; Pitra, Tomas; Eret, Viktor; Ürge, Tomas; Eberlová, Lada; Rousarova, Milena; Hošek, Petr; Chudáček, Zdenek; Ferda, Jiri; Hes, Ondrej; Hora, Milan (2017): Morphological Characterization of Papillary Renal Cell Carcinoma Type 1, the Efficiency of Its Surgical Treatment. In: Urologia internationalis, Vol. 98, No. 2: pp. 148-155
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Abstract

Aim: Papillary renal cell carcinoma type 1 (pRCC1) represents the second most common type of malignant renal epithelial tumour. The origin of its characteristic appearance, its growth mechanism, and the long-term efficiency of its surgical treatment remain uncertain. Our aim was to determine typical characteristics of surgically treated pRCC1. Methods: pRCC1 was verified in 83 of 1,629 (5.1%) kidney tumours surgically treated in the period of January 2007 January 2016. The clinical and radiological characteristics, type of surgery, histopathology results and follow up data were recorded. Spearman correlation, Kruskal Wallis analysis of variance, Fisher's exact, and chi-square test were used to analyse appropriate variables. The overall survival rate was evaluated using the Gehan Wilcoxon test and the Cox proportional hazards model. Results: The mean tumour size was 52.0 mm (15-180);98.8% of the tumours showed a spherical shape and in 82.1%, exophytic growth was observed. Partial nephrectomy was performed in 80.7%. A majority (81.9%) were classified as pT1. Tumours, 89.2% of them, belonged to Fuhrman grade 1 or 2. The mean follow-up was 46.8 months. The overall survival was associated with pT category (p <= 0.0001). Conclusions: Typical signs of pRCC1 are a spherical shape, exophytic growth and low Fuhrman's grade. More than three-fourths of pRCC1 could be treated by the nephron-sparing surgery. (C) 2016 S. Karger AG, Basel