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Reiner, M. F.; Stivala, S.; Limacher, A.; Bonetti, N. R.; Méan, M.; Egloff, M.; Rodondi, N.; Aujesky, D.; Schacky, C. von; Lüscher, T. F.; Camici, G. G.; Beer, J. H. (2017): Omega-3 fatty acids predict recurrent venous thromboembolism or total mortality in elderly patients with acute venous thromboembolism. In: Journal of thrombosis and Haemostasis, Vol. 15, No. 1: pp. 47-56
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Abstract

BackgroundThe role of omega-3 fatty acids (n-3 FAs) in recurrent venous thromboembolism (VTE) remains unknown. Objectives To investigate the association of n-3 FAs with recurrent VTE or total mortality at 6months and 3years. Methods N-3 FAs were assessed in 826 patients aged 65years, categorized into low, medium and high based on the 25th and 75th percentile. Mean follow-up was 29months. Results At 6months, subjects with medium (adjusted hazard ratio [HR], 0.37;95% confidence interval [CI], 0.22-0.62) and high n-3 FA levels (adjusted HR, 0.36;95% CI, 0.20-0.67) were less likely to develop recurrent VTE or total mortality, compared with those with low n-3 FAs. At 3years, medium levels (adjusted HR, 0.67;95% CI, 0.47-0.96) were associated with lower risk of recurrent VTE or total mortality. As compared with low n-3 FAs, the adjusted sub-hazard ratio [SHR] of recurrent VTE was 0.39 (95% CI, 0.15-0.99) in patients with medium and 0.17 (95% CI, 0.03-0.82) in patients with high n-3 FAs. The cumulative incidence of recurrent VTE was lower in the medium and high n-3 FA groups as compared with the low n-3 FA groups, but seems to have worn off after 3years. The incidence of major and non-major bleeding was not greater in the high n-3 FA group. Conclusion Higher levels of n-3 FAs were associated with a lower risk of recurrent VTE or total mortality in elderly patients with VTE, but not with greater bleeding risk.