Chromium-Catalyzed Cross-Coupling Reactions of Alkylmagnesium Reagents with Halo-Quinolines and Activated Aryl Chlorides

Bellan, Andreas B.; Kuzmina, Olesya M.; Vetsova, Violeta A. und Knochel, Paul (2017): Chromium-Catalyzed Cross-Coupling Reactions of Alkylmagnesium Reagents with Halo-Quinolines and Activated Aryl Chlorides. In: Synthesis-Stuttgart, Bd. 49, Nr. 1: S. 188-194

Abstract

An efficient protocol for chromium(III)-catalyzed C(sp(2))-C(sp(3)) cross-coupling is reported. The alkylations of halo-quinoline and phenacyl derivatives proceed at room temperature within minutes using the tetrahydrofuran-soluble chromium(III) complex CrCl3 center dot 3THF. The reactions occur without the formation of homo-coupling side products, which are common for the related iron-, cobalt-or manganese-catalyzed cross-coupling reactions.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0039-7881
• Sprache: Englisch