Chromium-Catalyzed Cross-Coupling Reactions of Alkylmagnesium Reagents with Halo-Quinolines and Activated Aryl Chlorides

Bellan, Andreas B.; Kuzmina, Olesya M.; Vetsova, Violeta A. and Knochel, Paul (2017): Chromium-Catalyzed Cross-Coupling Reactions of Alkylmagnesium Reagents with Halo-Quinolines and Activated Aryl Chlorides. In: Synthesis-Stuttgart, Vol. 49, No. 1: pp. 188-194

Abstract

An efficient protocol for chromium(III)-catalyzed C(sp(2))-C(sp(3)) cross-coupling is reported. The alkylations of halo-quinoline and phenacyl derivatives proceed at room temperature within minutes using the tetrahydrofuran-soluble chromium(III) complex CrCl3 center dot 3THF. The reactions occur without the formation of homo-coupling side products, which are common for the related iron-, cobalt-or manganese-catalyzed cross-coupling reactions.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 0039-7881
• Language: English