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Bellan, Andreas B.; Kuzmina, Olesya M.; Vetsova, Violeta A.; Knochel, Paul (2017): Chromium-Catalyzed Cross-Coupling Reactions of Alkylmagnesium Reagents with Halo-Quinolines and Activated Aryl Chlorides. In: Synthesis-Stuttgart, Vol. 49, No. 1: pp. 188-194
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An efficient protocol for chromium(III)-catalyzed C(sp(2))-C(sp(3)) cross-coupling is reported. The alkylations of halo-quinoline and phenacyl derivatives proceed at room temperature within minutes using the tetrahydrofuran-soluble chromium(III) complex CrCl3 center dot 3THF. The reactions occur without the formation of homo-coupling side products, which are common for the related iron-, cobalt-or manganese-catalyzed cross-coupling reactions.