Cutaneous squamous cell carcinoma with perineural invasion: Report on eight cases and review of the literature

Verburg, Maurice; Lang, Martin; Mühlstädt, Michael; Klein, Annette; Schauber, Jürgen; Sattler, Elke C. und Kunte, Christian (2015): Cutaneous squamous cell carcinoma with perineural invasion: Report on eight cases and review of the literature. In: Dermatology, Bd. 230, Nr. 2: S. 135-142

Abstract

BACKGROUND Perineural invasion (PNI) in cutaneous squamous cell carcinoma (SCC) is considered to be a negative prognostic factor. A lot of uncertainty remains regarding the classification, diagnosis, treatment and prognosis of SCC with PNI. OBJECTIVE To describe typical courses of SCC with PNI and associated findings in order to suggest an optimized diagnostic and therapeutic approach. METHODS We present eight cases of SCC with PNI, considering patient and tumor characteristics, histology, treatment and clinical course regarding local recurrence and metastasization. RESULTS SCC patients with PNI have a higher rate of local recurrences and greater risk for metastasization than SCC patients without PNI. Age ranged from 68 to 77 years, 6 patients were male and 2 female, with all tumors localized on the head. Three patients had chronic lymphocytic leukemia. CONCLUSION Based on the data of this series and the current literature, we make suggestions for better diagnostic and therapeutic management.

• Dokumententyp: Zeitschriftenartikel
• Publikationsform: Publisher's Version
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1018-8665
• Allianz-/Nationallizenz: Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
• Sprache: Englisch