Attenuation resilient AIF estimation based on hierarchical Bayesian modelling for first pass myocardial perfusion MRI

Schmid, Volker J. ; Gatehouse, Peter D. and Yang, Guang-Zhong (2007): Attenuation resilient AIF estimation based on hierarchical Bayesian modelling for first pass myocardial perfusion MRI. , Australien, 29. Oktober - 2. November 2007. Ayache, Nicholas; Ourselin, Sébastien and Maeder, Anthony (eds.) : In: Medical image computing and computer-assisted intervention - MICCAI 2007. 1, Vol. 4791 Springer. pp. 393-400

Abstract

Non-linear attenuation of the Arterial Input Function (AIF) is a major problem in first-pass MR perfusion imaging due to the high concentration of the contrast agent in the blood pool. This paper presents a technique to reconstruct the true AIF using signal intensities in the myocardium and the attenuated AIF based on a Hierarchical Bayesian Model (HBM). With the proposed method, both the AIF and the response function are modeled as smoothed functions by using Bayesian penalty splines (P-Splines). The derived AIF is then used to estimate the impulse response of the myocardium based on deconvolution analysis. The proposed technique is validated both with simulated data using the MMID4 model and ten in vivo data sets for estimating myocardial perfusion reserve rates. The results demonstrate the ability of the proposed technique in accurately reconstructing the desired AIF for myocardial perfusion quantification. The method does not involve any MRI pulse sequence modification, and thus is expected to have wider clinical impact.

• Item Type: Conference or Workshop Item (Report)
• Keywords: Myocardial Perfusion; Cardiovascular Magnetic Resonanc; Arterial Input Function; Hierarchical Bayesian Model; Myocardial Perfusion Reserve
• Faculties: Mathematics, Computer Science and Statistics > Statistics > Chairs/Working Groups > Bioimaging
• Subjects: 500 Science > 510 Mathematics; 600 Technology > 610 Medicine and health
• Language: English