A Concept for a Novel Test for Chemical Parity

Langhals, Heinz und Krotz, Oswald (2018): A Concept for a Novel Test for Chemical Parity. In: Green and Sustainable Chemistry, Bd. 8, Nr. 4: S. 311-319

Abstract

Deviations from chemical parity (PV) were evaluated with the search for very small enantiomeric excesses in a racemate prepared from non chiral materials and were detected by means of the circular dichroism (CD). Thus, intensely light-absorbing perylenebiscarboximides were attached to axially chiral biphenyls for the amplification of CD effects by exciton interactions of the adjacent chromophores. A rapidly racemising system was applied for the exclusion of artifacts and compared with an analogous with locked chirally. A very slight enantiomeric excess was detected for the (M) enantiomer. Application of the method for other systems was suggested and relations to natural products discussed.

• Dokumententyp: Zeitschriftenartikel
• Publikationsform: Publisher's Version
• Keywords: Chirality; Parity; Circular Dichroism; UV/Vis Spectroscopy; Racemates
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 2160-696X
• Sprache: Englisch