Logo Logo
Hilfe
Hilfe
Switch Language to English

Fleissner, Felix; Redwan, Ahmed; Bisdas, Theodosios; Boeck, Anna-Lena; Weissenborn, Karin; Haverich, Axel; Teebken, Omke E.; Pichlmaier, Maximilian und Martens, Andreas (2015): Intraoperative Changes in Cerebrospinal Fluid Gas Tensions Reflect Paraplegia During Thoracoabdominal Aortic Surgery. A Proof-of-Principle Study. In: Vascular and Endovascular Surgery, Bd. 49, Nr. 3-4: S. 84-92 [PDF, 398kB]

[thumbnail of 1538574415595210.pdf]
Vorschau
Download (398kB)

Abstract

Background: In this study, gas tensions in cerebrospinal fluid (CSF) were prospectively evaluated as intraoperative markers for the detection of neurological deficits. Methods: Spinal fluid, serum, and heart lung machine (HLM) perfusate were monitored for gas tensions (po2/pCo2) and related parameters (pH, lactate, and glucose) during thoracoabdominal aortic repair and correlated with perioperative neurological examination and electrophysiological testing. Results: Forty-seven patients were assessed for the study, and 40 consecutive patients were finally included. The patients were divided into 3 groups: group A (23 patients, 57.5%): no clinical or laboratory signs of neurological damage; group B (14 patients, 35%) who developed subclinical deficits; and group C (3 patients, 7.5%) who had paraplegia. Significant intraoperative changes in CSF gas tensions were observed with postoperative paraplegia. Glucose ratio between serum and CSF showed higher variability in group C, confirming a damage of the blood–brain barrier (BBB). Conclusion: Major neurological damage is reflected by early changes in CSF gas tensions and glucose variability, suggesting damage of the BBB in these patients.

Dokument bearbeiten Dokument bearbeiten