Chemodivergent and Stereoselective Access to Fused Isoxazoline Azetidines and Thietanes through 3 + 2-Cycloadditions

Baumann, Andreas N.; Reiners, Felix; Juli, Thomas und Didier, Dorian (2018): Chemodivergent and Stereoselective Access to Fused Isoxazoline Azetidines and Thietanes through 3 + 2-Cycloadditions. In: Organic Letters, Vol. 20, No. 21: pp. 6736-6740

Abstract

By combining efficient methodologies for the preparation of substituted azetines and thietes with a highly regio- and diastereoselective 3 + 2-cycloaddition, a straightforward pathway for the synthesis of fused isoxazoline azetidines and thietanes has been designed. With minimal steps and starting from commercial sources, a new library of elaborated architectures was synthesized opening up a new class of molecules with large potential in pharmacology. Finally, a retro 2 + 2-cycloaddition leading to substituted isoxazoles is described.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1523-7060
• Language: English