Inhibition enhances memory capacity: optimal feedback, transient replay and oscillations

Kammerer, Axel; Tejero-Cantero, Alvaro; Leibold, Christian (2013): Inhibition enhances memory capacity: optimal feedback, transient replay and oscillations. In: Journal of Computational Neuroscience, Vol. 34, No. 1: pp. 125-136

Abstract

Recurring sequences of neuronal activation in the hippocampus are a candidate for a neurophysiological correlate of episodic memory. Here, we discuss a mean-field theory for such spike sequences in phase space and show how they become unstable when the neuronal network operates at maximum memory capacity. We find that inhibitory feedback rescues replay of the sequences, giving rise to oscillations and thereby enhancing the network's capacity. We further argue that transient sequences in an overloaded network with feedback inhibition may provide a mechanistic picture of memory-related neuronal activity during hippocampal sharp-wave ripple complexes.

• Item Type: Journal article
• Faculties: Biology > Department Biology II > Neurobiology
• Subjects: 500 Science > 570 Life sciences; biology
• ISSN: 0929-5313
• Language: English