Abstract
The medial nucleus of the trapezoid body (MNTB) in the superior olivary complex (SOC) is an inhibitory hub considered critical for binaural sound localization. We show that genetic ablation of MNTB neurons in mice only subtly affects this ability by prolonging the minimum time required to detect shifts in sound location. Furthermore, glycinergic innervation of the SOC is maintained without an MNTB, consistent with the existence of parallel inhibitory inputs. These findings redefine the role of MNTB in sound localization and suggest that the inhibitory network is more complex than previously thought.
Dokumententyp: | Zeitschriftenartikel |
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Fakultät: | Biologie > Department Biologie II > Neurobiologie |
Themengebiete: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie |
ISSN: | 0270-6474 |
Sprache: | Englisch |
Dokumenten ID: | 61498 |
Datum der Veröffentlichung auf Open Access LMU: | 27. Mrz. 2019, 10:22 |
Letzte Änderungen: | 04. Nov. 2020, 13:39 |