Logo Logo
Help
Contact
Switch Language to German

Okamura, Hidenori ORCID logoORCID: https://orcid.org/0000-0002-2792-9595; Becker, Sidney ORCID logoORCID: https://orcid.org/0000-0002-4746-2822; Tiede, Niklas; Wiedemann, Stefan; Feldmann, Jonas ORCID logoORCID: https://orcid.org/0000-0002-3887-2213 and Carell, Thomas ORCID logoORCID: https://orcid.org/0000-0001-7898-2831 (7. January 2019): A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions. In: Chemical Communications, Vol. 55: pp. 1939-1942 [PDF, 2MB]

[thumbnail of Okamura_ChemCommun_2019.pdf]
Preview
Published Version
Download (2MB)

Abstract

Herein, we report a new prebiotically plausible pathway towards a pyrimidine nucleobase in continuous manner. The route involves simultaneous methylation and carbamoylation of cyanoacetylene-derived alpha,beta-unsaturated thioamide with N-methyl-N-nitrosourea (MNU) in aqueous media. This provides S-methylpyrimidinone in one-pot, which can be converted into a variety of 4-substituted pyrimidine nucleobases including cytosine and uracil.

Actions (login required)

View Item View Item