Abstract
Background: Many studies have examined the relationship between vitamin D and specific types of cancer with inconsistent results. Furthermore, to date, no observational studies have demonstrated a clear relationship between vitamin D and total cancer risk. Methods: We analyzed data from a population-based prospective cohort study including 2,003 initially cancer-free participants from the KORA F4 study with baseline serum 25-hydroxyvitamin D (25(OH) D) measurements (surveyed between 2006 and 2008). We used Cox proportional hazard models to assess the association between 25(OH) D levels and incident cancer risk. Results: Within a follow-up period of 7 years, 69 of the participants developed cancer. Overall, we observed no significant relationship between serum 25(OH) D levels and cancer risk. The hazard ratio (HR) per 1 ng/ml increase in 25 (OH) D for this relationship was 1.00 (95% confidence interval (CI) 0.97-1.04) adjusting for age, sex, body mass index, and season of blood draw. This was also true in subgroup analysis for prostate cancer (HR 0.95, 95% CI 0.88-1.03), breast cancer (HR 1.03, 95% CI 0.97-1.09), and colorectal cancer (HR 0.97, 95% CI 0.88-1.07). Conclusion: Our study found no protective effect of 25(OH) D against developing cancer. However, studies with more participants and additional measurements of 25(OH) D are still needed to accurately clarify the relationship between 25(OH) D and total cancer risk.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Fakultät: | Medizin
Geowissenschaften > Department für Geographie |
| Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
500 Naturwissenschaften und Mathematik > 550 Geowissenschaften, Geologie |
| ISSN: | 2296-5270 |
| Sprache: | Englisch |
| Dokumenten ID: | 63096 |
| Datum der Veröffentlichung auf Open Access LMU: | 19. Jul. 2019, 12:12 |
| Letzte Änderungen: | 04. Nov. 2020, 13:41 |
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