Four-dimensional optoacoustic temperature mapping in laser-induced thermotherapy

Landa, Francisco Javier Oyaga; Dean-Ben, Xose Luis; Sroka, Ronald und Razansky, Daniel (2018): Four-dimensional optoacoustic temperature mapping in laser-induced thermotherapy. In: Photons Plus Ultrasound: Imaging and Sensing 2018, Nr. 104940D

Abstract

Photoablative laser therapy is in common use for selective destruction of malignant masses, vascular and brain abnormalities. Tissue ablation and coagulation are irreversible processes occurring shortly after crossing a certain thermal exposure threshold. As a result, accurate mapping of the temperature field is essential for optimizing the outcome of these clinical interventions. Here we demonstrate four-dimensional optoacoustic temperature mapping of the entire photoablated region. Accuracy of the method is investigated in tissue-mimicking phantom experiments. Deviations of the volumetric optoacoustic temperature readings provided at 40ms intervals remained below 10% for temperature elevations above 3 degrees C, as validated by simultaneous thermocouple measurements. The excellent spatio-temporal resolution of the new temperature monitoring approach aims at improving safety and efficacy of laser-based photothermal procedures.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0277-786X
• Sprache: Englisch