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Anslinger, K.; Bayer, B.; Mariassy, D. von (2018): Application of DEPArray (TM) technology for the isolation of white blood cells from cell mixtures in chimerism analysis. In: Rechtsmedizin, Vol. 28, No. 2: pp. 134-137
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After allogeneic bone marrow or blood stem cell transplantation, STR profiling is often used for monitoring chimerisms. For the evaluation reference samples taken from the patient before the transplantation and/or taken from the donor are needed. In the case described here, no reference samples were available. Reporting the chimerism based on posttransplantation samples did not yield conclusive results;therefore, white blood cells and epithelial cells obtained from a buccal swab taken from the patient were separated using DEPArray(TM) technology and STR profiling was carried out resulting in distinct reference profiles.