Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma

Gerbes, Alexander; Zoulim, Fabien; Tilg, Herbert; Dufour, Jean-Francois; Bruix, Jordi; Paradis, Valerie; Salem, Riad; Peck-Radosavljevic, Markus; Galle, Peter R.; Greten, Tim F.; Nault, Jean-Charles and Avila, Matias A. (2018): Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma. In: Gut, Vol. 67, No. 2: pp. 380-388

Abstract

Hepatocellular carcinoma (HCC) ranks number three among the most frequent causes of death from solid tumors worldwide. With obesity and fatty liver diseases as risk factors on the rise, HCC represents an ever increasing challenge. While there is still no curative treatment for most patients numerous novel drugs have been proposed, but most ultimately failed in phase III trials. This manuscript targets therapeutic advances and most burning issues. Expert key point summaries and urgent research agenda are provided regarding risk factors, including microbiota, need for prognostic and predictive biomarkers and the equivocal role of liver biopsy. Therapeutic topics highlighted are locoregional techniques, combination therapies and the potential of immunotherapy. Finally the manuscript provides a critical evaluation of novel targets and strategies for personalized treatment of HCC.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0017-5749
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Language: English