Abstract
IL-31 is a novel cytokine expressed in many human tissues and involved mainly in T(H)2-weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31 receptor a and oncostatin M receptor b. The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target for directed drug therapy. Regulation of immune responses and cellular differentiation and proliferation are recently elucidated effects of IL-31, suggesting a more complex and diverse area of effect for this novel cytokine. This review summarizes the current knowledge on IL-31 and its receptors and the involvement of IL-31 in diseases both in human subjects and mouse models.
| Item Type: | Journal article |
|---|---|
| Faculties: | Medicine |
| Subjects: | 600 Technology > 610 Medicine and health |
| ISSN: | 0091-6749 |
| Language: | English |
| Item ID: | 63972 |
| Date Deposited: | 19. Jul 2019, 12:14 |
| Last Modified: | 04. Nov 2020, 13:42 |
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