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Brandlhuber, Martina; Genzinger, Christian; Brandlhuber, Bernhard; Sommer, Wieland H.; Müller, Mario H.; Kreis, Martin E. (2018): Long-term quality of life after conservative treatment versus surgery for different stages of acute sigmoid diverticulitis. In: International Journal of Colorectal Disease, Vol. 33, No. 3: pp. 317-326
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Abstract

It is controversial whether patients fare better with conservative or surgical treatment in certain stages of acute diverticulitis (AD), in particular when phlegmonous inflammation or covered micro- or macro-perforation are present. The aim of this study was to determine long-term quality of life (QoL) for AD patients who received either surgery or conservative treatment in different stages. We included patients treated for AD at the University Hospital Grosshadern, Munich, Germany, between January 1, 2000, and December 31, 2010. Patients were classified by the Hansen and Stock (HS) classification, the modified Hinchey classification, and the German classification of diverticular disease (CDD). Pre-therapeutic staging was based on multidetector computed tomography. Long-term QoL was assessed by the Cleveland Global Quality of Life (CGQL) questionnaire, the Short Form 36 (SF-36), and the Gastrointestinal Quality of Life Index (GIQLI). Data are mean +/- SEM. Patients with phlegmonous AD (HS type 2a, Hinchey Ia and CDD 1b, respectively) had a better long-term QoL on the GIQLI when they were operated (78.5 +/- 2.5 vs. 70.7 +/- 2.1;p < 0.05). Patients with micro-abscess (CDD 2a) had a better long-term QoL on the GIQLI, CGQL, and the "Role Physical" scale of the SF-36 when they were not operated (GIQLI 86.9 +/- 2.1 vs. 76.8 +/- 1.0;p = 0.10;CGQL 82.8 +/- 5.1 vs. 65.3 +/- 11.0;p = 0.08;SF-36/Role Physical 100 +/- 0.0 vs. 41.7 +/- 13.9;p < 0.001). Patients with macro-abscess (CDD 2b) had a better long-term QoL when they were operated (GIQLI 89.3 +/- 1.4 vs. 69.5 +/- 4.5;p < 0.01;CGQL 80.3 +/- 7.6 vs. 60.5 +/- 5.8;p < 0.05;SF-36/Role Physical 95.8 +/- 4.2 vs. 47.9 +/- 13.6;p < 0.001). Considering long-term QoL, phlegmonous AD (HS type 2a, Hinchey Ia and CDD 1b, respectively) should be treated conservatively. In patients with covered perforation, abscess size should guide the decision on whether to perform surgery later on or not. In the light of long-term quality of life, patients fare better after elective sigmoid colectomy when abscess size exceeds 1 cm.