Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and-9

Schulz, Heiko; Kuhn, Christina; Hofmann, Simone; Mayr, Doris; Mahner, Sven; Jeschke, Udo und Schmoeckel, Elisa (2018): Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and-9. In: International Journal of Molecular Sciences, Bd. 19, Nr. 1, 323

Abstract

The evaluation of new prognostic factors that can be targeted in ovarian cancer diagnosis and therapy is of the utmost importance. Galectins are a family of carbohydrate binding proteins with various implications in cancer biology. In this study, the presence of galectin (Gal)-8 and -9 was investigated in 156 ovarian cancer samples using immunohistochemistry (IHC). Staining was evaluated using semi-quantitative immunoreactivity (IR) scores and correlated to clinical and pathological data. Different types of galectin expression were compared with respect to disease-free survival (DFS) and overall survival (OS). Gal-8 served as a new positive prognostic factor for the OS and DFS of ovarian cancer patients. Gal-9 expression determined the DFS and OS of ovarian cancer patients in two opposing waysmoderate Gal-9 expression was correlated with a reduced outcome as compared to Gal-9 negative cases, while patients with high Gal-9 expression showed the best outcome.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1422-0067
• Sprache: Englisch