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Koelbl, Alexandra C.; Schlenk, Kristina; Behrendt, Nils; Andergassen, Ulrich (2018): The importance of hCG in human endometrial adenocarcinoma and breast cancer. In: International Journal of Biological Markers, Vol. 33, No. 1: pp. 33-39
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Human chorionic gonadotropin (hCG) is a peptide hormone which plays an important role during pregnancy. But its impact is not limited to pregnancy;it also influences tumor formation and metastatic outgrowth, especially in endometrial adenocarcinoma and breast cancer. This review summarizes what has been written in the literature about the role of hCG as a tumor marker in these 2 gynecological malignancies and also about the signal transduction pathways in which hCG is involved. HCG can, on the one hand, be a marker for the progression of a malignant disease, and on the other hand, it may be a point for therapeutical intervention, so further research into this molecule would be very much worthwhile.