Maternal plasma n-3 and n-6 polyunsaturated fatty acids during pregnancy and features of fetal health: Fetal growth velocity, birth weight and duration of pregnancy

Grootendorst-van Mil, Nina H.; Tiemeier, Henning; Steenweg-de Graaff, Jolien; Koletzko, Berthold; Demmelmair, Hans; Jaddoe, Vincent W. V.; Steegers, Eric A. P. and Steegers-Theunissen, Regine P. M. (2018): Maternal plasma n-3 and n-6 polyunsaturated fatty acids during pregnancy and features of fetal health: Fetal growth velocity, birth weight and duration of pregnancy. In: Clinical Nutrition, Vol. 37, No. 4: pp. 1367-1374

Abstract

Background & aims: Maternal fatty acids are essential for fetal growth and development. Here, we examine associations between maternal mid-pregnancy plasma n-3 and n-6 polyunsaturated fatty acids (PUFAs) and fetal health determined by fetal growth velocity, birth weight and duration of pregnancy. Methods: Participants were 6974 pregnant women and their infants from a population-based birth cohort, the Generation R Study. Maternal plasma n-3:n-6 PUFA ratio and n-3 and n-6 PUFA percentage in glycerophospholipids in mid-pregnancy were related to fetal growth velocity calculated from repeatedly measured weight, length and head circumference, birth weight, and duration of pregnancy. Results: A higher maternal mid-pregnancy n-3:n-6 PUFA ratio was associated with a higher growth velocity of the fetal weight (beta = 0.082 SD-score/week, 95% CI 0.055;0.108, P < 0.001), length (beta = 0.085 SD-score/week, 95% CI 0.052;0.119, P < 0.001);and head (beta = 0.055 SD-score/week, 95% CI 0.019;0.091, P = 0.003). We also observed positive associations between n-3:n-6 PUFA ratio and birth weight (beta = 0.76 SD-score, 95% CI 0.22;1.29, P = 0.006), and duration of pregnancy (beta = 1.32 weeks, 95% CI 0.24;2.40, P = 0.02). Conclusions: These results are consistent with the hypothesis that a higher n-3:n-6 PUFA ratio is important for fetal health.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0261-5614
• Language: English