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Karrasch, Stefan ORCID logoORCID: https://orcid.org/0000-0001-9807-2915; Radtke, T.; Simon, M.; Kronseder, A.; Dressel, H.; Jörres, Rudolf A. ORCID logoORCID: https://orcid.org/0000-0002-9782-1117 and Ochmann, Uta ORCID logoORCID: https://orcid.org/0009-0003-3454-9691 (2018): Acute effects of hypertonic saline inhalation on nitric oxide pulmonary diffusing capacity in healthy adults. In: Respiratory Physiology & Neurobiology, Vol. 258: pp. 40-46

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We investigated acute effects of inhalation of hypertonic saline solution (HSS) and oxygen (O-2, control exposure) on pulmonary diffusing capacity for nitric oxide (DLNO) and carbon monoxide (DLCO). In a randomized crossover study, 20 healthy, non-smoking subjects were allocated to short-term inhalation of HSS or O-2. Spirometry [(forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC)] and combined single breath DLNO-DLCO measurements were performed before and immediately after inhalation of either HSS or O-2. Percent changes were presented as median values (interquartile range). After HSS inhalation, DLNO, FEV1 and FVC were decreased by -3.0% (-7.3, 0.5), -3.1% (-4.2, -1.6) and -1.2% (-3.3, 0.6), respectively (all P < 0.05), without significant effect on DLCO. No changes in spirometry and diffusing capacity were observed following O-2 inhalation. Acute inhalation of HSS causes a slight decrease in membrane conductance, probably as a result of fluid imbalance at the alveolar surface and interstitial fluid accumulation, both of which could impair gas exchange.

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