Abstract
Osteonecrosis (ON) was prospectively assessed in 557 children and adolescents in the Berlin-Frankfurt-Munster Stem Cell Transplantation in children with acute lymphoblastic leukaemia 2003 trial. Median age at haematopoietic stem cell transplantation (HSCT) was 103years (range 05-26). Cumulative incidence of symptomatic ON (sON) was 9% at 5years (standard deviation 1%), median time from HSCT to diagnosis of sON was 124months (range 1-126). Multivariate analysis identified age at HSCT [10-15years vs. <10years: hazard ratio (HR) 373, P=0009;>15years vs. <10years: HR 546, P=0001], diagnosis of sON prior to HSCT and chronic graft-versus-host disease (yes versus no: HR 2696, P=0015) as significant independent risk factors for the development of sON.
Dokumententyp: | Zeitschriftenartikel |
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Fakultät: | Medizin |
Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
ISSN: | 0007-1048 |
Sprache: | Englisch |
Dokumenten ID: | 64554 |
Datum der Veröffentlichung auf Open Access LMU: | 19. Jul. 2019, 12:15 |
Letzte Änderungen: | 04. Nov. 2020, 13:44 |