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Kuhlen, Michaela; Bader, Peter; Sauer, Martin; Albert, Michael H.; Gruhn, Bernd; Gungor, Tayfun; Kropshofer, Gabriele; Lang, Peter; Lawitschka, Anita; Metzler, Markus; Pentek, Falk; Rossig, Claudia; Schlegel, Paul G.; Schrappe, Martin; Schrum, Johanna; Schulz, Ansgar; Schwinger, Wolfgang; Stackelberg, Arend von; Strahm, Brigitte; Suttorp, Meinolf; Teichert-von Luettichau, Irene; Woessmann, Wilhelm; Borkhardt, Arndt; Meisel, Roland; Poetschger, Ulrike; Glogova, Evgenia; Peters, Christina (2018): Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high‐risk or relapsed ALL – results of the ALL‐SCT 2003 trial. In: British Journal of Haematology, Vol. 183, No. 1: pp. 104-109
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Abstract

Osteonecrosis (ON) was prospectively assessed in 557 children and adolescents in the Berlin-Frankfurt-Munster Stem Cell Transplantation in children with acute lymphoblastic leukaemia 2003 trial. Median age at haematopoietic stem cell transplantation (HSCT) was 103years (range 05-26). Cumulative incidence of symptomatic ON (sON) was 9% at 5years (standard deviation 1%), median time from HSCT to diagnosis of sON was 124months (range 1-126). Multivariate analysis identified age at HSCT [10-15years vs. <10years: hazard ratio (HR) 373, P=0009;>15years vs. <10years: HR 546, P=0001], diagnosis of sON prior to HSCT and chronic graft-versus-host disease (yes versus no: HR 2696, P=0015) as significant independent risk factors for the development of sON.