Calcium signalling and related ion channels in neutrophil recruitment and function

Immler, Roland; Simon, Scott I. und Sperandio, Markus (2018): Calcium signalling and related ion channels in neutrophil recruitment and function. In: European Journal of Clinical Investigation, Bd. 48, Nr. Suppl. 2

Abstract

The recruitment of neutrophils to sites of inflammation, their battle against invading microorganisms through phagocytosis and the release of antimicrobial agents is a highly coordinated and tightly regulated process that involves the interplay of many different receptors, ion channels and signalling pathways. Changes in intracellular calcium levels, caused by cytosolic Ca2+ store depletion and the influx of extracellular Ca2+ via ion channels, play a critical role in synchronizing neutrophil activation and function. In this review, we provide an overview of how Ca2+ signalling is initiated in neutrophils and how changes in intracellular Ca2+ levels modulate neutrophil function.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0014-2972
• Sprache: Englisch