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Bhuiyan, Tanveer A.; Graff, Claus; Kanters, Jorgen K.; Melgaard, Jacob; Toft, Egon; Kääb, Stefan; Struijk, Johannes J. (2018): A History of Drug‐Induced Torsades de Pointes Is Associated With T‐wave Morphological Abnormalities. In: Clinical Pharmacology & Therapeutics, Vol. 103, No. 6: pp. 1100-1106
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Abstract

The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 +/- 9 ms;-TdP: QTcF = 431 +/- 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 +/- 0.095;-TdP: MCS = 0.74 +/- 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and -TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone.