Abstract
Atrial fibrillation is the most common arrhythmia and affects several million patients worldwide. Over the last years, a strong genetic influence on atrial fibrillation has been identified. A recent study could quantify the heritability of atrial fibrillation to 22.1%. Clinically, this translates into the relevance of family history for atrial fibrillation. In addition to rare mutations, for example in ion channel coding genes, common genetic variants, so-called single nucleotide polymorphisms, have been identified as the major contributor to atrial fibrillation heritability. So far, genome-wide association studies have identified 97 genetic loci that are associated with an increased risk of atrial fibrillation. Most of these polymorphisms are located in proximity to genes with impact on electrophysiology, cardiac structure, or development. In most instances however, the cellular and molecular mechanisms how these genetic variants confer to an increased atrial fibrillation risk are unknown. To further evaluate those underlying mechanisms, extensive investigations in cellular and animal model systems are warranted.
| Item Type: | Journal article |
|---|---|
| Faculties: | Medicine |
| Subjects: | 600 Technology > 610 Medicine and health |
| ISSN: | 2193-5203 |
| Language: | German |
| Item ID: | 64835 |
| Date Deposited: | 19. Jul 2019, 12:16 |
| Last Modified: | 04. Nov 2020, 13:44 |
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